NEGATIVE CONTROL OF PHOTORECEPTOR DEVELOPMENT IN DROSOPHILA BY THE PRODUCT OF THE YAN GENE, AN ETS DOMAIN PROTEIN

被引：237

作者：

LAI, ZC ^{[1
]}

RUBIN, GM ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,BERKELEY,CA 94720

来源：

CELL | 1992年 / 70卷 / 04期

关键词：

D O I：

10.1016/0092-8674(92)90430-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.

引用

页码：609 / 620

页数：12

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