THE ORIGIN AND FUNCTION OF TUMOR-ASSOCIATED MACROPHAGES

被引：888

作者：

MANTOVANI, A ^{[1
]}

BOTTAZZI, B ^{[1
]}

COLOTTA, F ^{[1
]}

SOZZANI, S ^{[1
]}

RUCO, L ^{[1
]}

机构：

[1] UNIV LA SAPIENZA,DEPT BIOPATHOL,I-00100 ROME,ITALY

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 07期

关键词：

D O I：

10.1016/0167-5699(92)90008-U

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor-associated macrophages (TAM) hate a complex relationship with the neoplastic cells of the tumor. On the one hand, the two cell types produce reciprocal growth factors and may be considered to have a symbiotic relationship. On the other hand, TAM can be activated to inhibit tumor growth and destroy neoplastic cells. Here, Alberto Mantovani and colleagues describe this delicate balance and the prospects for its therapeutic manipulation.

引用

页码：265 / 270

页数：6

共 66 条

[1] HUMAN-TUMOR CELL-LINES WITH PLEIOTROPIC DRUG-RESISTANCE ARE EFFICIENTLY KILLED BY INTERLEUKIN-2 ACTIVATED KILLER-CELLS AND BY ACTIVATED MONOCYTES [J].