CLASS-II-ANTIGEN-NEGATIVE PATIENT AND MUTANT B-CELL LINES REPRESENT AT LEAST 3, AND PROBABLY 4, DISTINCT GENETIC-DEFECTS DEFINED BY COMPLEMENTATION ANALYSIS

被引：130

作者：

BENICHOU, B

STROMINGER, JL

机构：

[1] Dept. of Biochem. and Molec. Biology, Harvard University, Cambridge

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 10期

关键词：

D O I：

10.1073/pnas.88.10.4285

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Expression of class II major histocompatibility complex antigens in defective B-lymphoblastoid cell lines from patients with class II antigen deficiency and from in vitro mutants generated with the same phenotype was studied. By heterogenetic fusion experiments, at least three, and probably four, complementation groups were defined. Furthermore, clone 13 (a DR-, DP-, but DQ+ cell line) appeared to belong to the RJ2.2.5 complementation group, for which all other members are DR-, DP-, and also DQ-. Thus, it is hypothesized that the cell lines of this group lack the activity of a gene that can differentially regulate the DR/DP and the DQ promoters.

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页码：4285 / 4288

页数：4

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