MICROBIOLOGIC OXIDATION OF ESTRATRIENES AND ESTRATETRAENES BY STREPTOMYCES-ROSEOCHROMOGENES ATCC-13400

被引：8

作者：

FERRER, JC ^{[1
]}

CALZADA, V ^{[1
]}

BONET, JJ ^{[1
]}

机构：

[1] CETS INST QUIM SARRIA,DEPT ORGAN CHEM,E-08017 BARCELONA,SPAIN

来源：

STEROIDS | 1990年 / 55卷 / 09期

关键词：

STEROIDS; ESTRATRIENES; ESTRATETRAENES; C-13; NMR; STREPTOMYCES-ROSEOCHROMOGENES ATCC-13400; MICROBIOLOGIC OXIDATION;

D O I：

10.1016/0039-128X(90)90096-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Incubation of estrone (1a) with Streptomyces roseochromogenes ATCC 13400 yielded a mixture of 3,16-alpha-dihydroxyestra-1,3,5(10)-trien-17-one (3a) and 3, 17-beta-dihydroxyestra-1,3,5(10)-trien-16-one (4a). Transformation of 3-methoxyestra-1,2,5(10)-trien-17-one (1b), 3-hydroxyestra-1,35(10),9(11)-tetraen-17-one (2a), and 3-methoxyestra-1,3,5(10),9(11)-tetraen-17-one (2b) with the same microorganism gave the corresponding mixtures of 16-alpha-hydroxy-17-ketones and 17-beta-hydroxy-16-ketones (3b and 4b, 6a and 7a, 6b and 7b, respectively). In addition, these three last experiments, the 16-beta-17-beta-dihydroxy derivatives 5b, 8a, and 8b, respectively, were also isolated. The complete assignments of the C-13 nuclear magnetic resonance spectra of these compounds are given.

引用

页码：390 / 394

页数：5

共 20 条

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