WAT is a functional adipocyte?

被引：33
作者：
Church, Christopher D. [1 ]
Horowitz, Mark C. [2 ]
Rodeheffer, Matthew S. [1 ,3 ,4 ]
机构：
[1] Yale Univ, Comparat Med Sect, New Haven, CT 06520 USA
[2] Yale Univ, Orthopaed & Rehabil, New Haven, CT 06520 USA
[3] Yale Univ, Dept Mol Cell & Dev Biol, New Haven, CT 06520 USA
[4] Yale Univ, Yale Stem Cell Ctr, New Haven, CT 06520 USA
来源：
ADIPOCYTE | 2012年 / 1卷 / 01期
关键词：
white adipose tissue; adipocyte; PPAR gamma; leptin; lipid; adiponectin;
D O I：
10.4161/adip.19132
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In vertebrates, adipose tissue is the main storage site for lipids within specialized lipid-laden mature adipocytes. While many species have evolved cells capable of lipid storage, the adipocyte represents a unique specialized cell involved in fuel storage, endocrine, nervous and immune function. However, the adipocytes are not the only cell type in mammals that can accumulate lipid droplets. The ectopic accumulation of lipid in non-adipose tissues including the liver, skeletal muscle, bone, pancreas, and heart in combination with its excessive accumulation in adipose tissue contributes to metabolic disease. Determining the lipid processing components that are necessary and sufficiently for lipid accumulation in adipose and non-adipose tissues, in addition to endocrine function, will lead to a clearer definition of an adipocyte.
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收藏
页码：38 / 45
页数：8
相关论文
共 128 条
[71]   Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity [J].
Meex, Ruth C. R. ;
Schrauwen-Hinderling, Vera B. ;
Moonen-Kornips, Esther ;
Schaart, Gert ;
Mensink, Marco ;
Phielix, Esther ;
van de Weijer, Tineke ;
Sels, Jean-Pierre ;
Schrauwen, Patrick ;
Hesselink, Matthijs K. C. .
DIABETES, 2010, 59 (03) :572-579
[72]  
Michalik L, 2002, INT J DEV BIOL, V46, P105
[73]   Functional conservation for lipid storage droplet association among perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium [J].
Miura, S ;
Gan, JW ;
Brzostowski, J ;
Parisi, MJ ;
Schultz, CJ ;
Londos, C ;
Oliver, B ;
Kimmel, AR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (35) :32253-32257
[74]   RED AND YELLOW MARROW IN THE FEMUR - AGE-RELATED-CHANGES IN APPEARANCE AT MR IMAGING [J].
MOORE, SG ;
DAWSON, KL .
RADIOLOGY, 1990, 175 (01) :219-223
[75]   Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts [J].
Moran-Salvador, Eva ;
Lopez-Parra, Marta ;
Garcia-Alonso, Veronica ;
Titos, Esther ;
Martinez-Clemente, Marcos ;
Gonzalez-Periz, Ana ;
Lopez-Vicario, Cristina ;
Barak, Yaacov ;
Arroyo, Vicente ;
Claria, Joan .
FASEB JOURNAL, 2011, 25 (08) :2538-2550
[76]   Intramuscular triacylglycerol and insulin resistance: Guilty as charged or wrongly accused? [J].
Muoio, Deborah M. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2010, 1801 (03) :281-288
[77]   The dynamic roles of intracellular lipid droplets: from archaea to mammals [J].
Murphy, Denis J. .
PROTOPLASMA, 2012, 249 (03) :541-585
[78]   The biogenesis and functions of lipid bodies in animals, plants and microorganisms [J].
Murphy, DJ .
PROGRESS IN LIPID RESEARCH, 2001, 40 (05) :325-438
[79]   Role of lipid bodies and lipid-body proteins in seeds and other tissues [J].
Murphy, DJ ;
Hernández-Pinzón, I ;
Patel, K .
JOURNAL OF PLANT PHYSIOLOGY, 2001, 158 (04) :471-478
[80]   Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis [J].
Neumeier, Markus ;
Hellerbrand, Claus ;
Gaebele, Erwin ;
Buettner, Roland ;
Bollheimer, Cornelius ;
Weigert, Johanna ;
Schaeffler, Andreas ;
Weiss, Thomas S. ;
Lichtenauer, Monika ;
Schoelmerich, Juergen ;
Buechler, Christa .
WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (34) :5490-5494
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