WAT is a functional adipocyte?

被引：33
作者：
Church, Christopher D. [1 ]
Horowitz, Mark C. [2 ]
Rodeheffer, Matthew S. [1 ,3 ,4 ]
机构：
[1] Yale Univ, Comparat Med Sect, New Haven, CT 06520 USA
[2] Yale Univ, Orthopaed & Rehabil, New Haven, CT 06520 USA
[3] Yale Univ, Dept Mol Cell & Dev Biol, New Haven, CT 06520 USA
[4] Yale Univ, Yale Stem Cell Ctr, New Haven, CT 06520 USA
来源：
ADIPOCYTE | 2012年 / 1卷 / 01期
关键词：
white adipose tissue; adipocyte; PPAR gamma; leptin; lipid; adiponectin;
D O I：
10.4161/adip.19132
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In vertebrates, adipose tissue is the main storage site for lipids within specialized lipid-laden mature adipocytes. While many species have evolved cells capable of lipid storage, the adipocyte represents a unique specialized cell involved in fuel storage, endocrine, nervous and immune function. However, the adipocytes are not the only cell type in mammals that can accumulate lipid droplets. The ectopic accumulation of lipid in non-adipose tissues including the liver, skeletal muscle, bone, pancreas, and heart in combination with its excessive accumulation in adipose tissue contributes to metabolic disease. Determining the lipid processing components that are necessary and sufficiently for lipid accumulation in adipose and non-adipose tissues, in addition to endocrine function, will lead to a clearer definition of an adipocyte.
引用
收藏
页码：38 / 45
页数：8
相关论文
共 128 条
[101]   STIMULATION OF ADIPOGENESIS IN FIBROBLASTS BY PPAR-GAMMA-2, A LIPID-ACTIVATED TRANSCRIPTION FACTOR [J].
TONTONOZ, P ;
HU, ED ;
SPIEGELMAN, BM .
CELL, 1994, 79 (07) :1147-1156
[102]   Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate [J].
Tse, Justin R. ;
Engler, Adam J. .
PLOS ONE, 2011, 6 (01)
[103]   Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle [J].
Uezumi, Akiyoshi ;
Fukada, So-ichiro ;
Yamamoto, Naoki ;
Takeda, Shin'ichi ;
Tsuchida, Kunihiro .
NATURE CELL BIOLOGY, 2010, 12 (02) :143-U116
[104]   Lipotoxic diseases [J].
Unger, RH .
ANNUAL REVIEW OF MEDICINE, 2002, 53 :319-336
[105]   Peroxisome proliferator-activated receptor gene expression in human tissues - Effects of obesity, weight loss, and regulation by insulin and glucocorticoids [J].
VidalPuig, AJ ;
Considine, RV ;
JimenezLinan, M ;
Werman, A ;
Pories, WJ ;
Caro, JF ;
Flier, JS .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (10) :2416-2422
[106]   Endocrine functions of adipose tissue [J].
Waki, Hironori ;
Tontonoz, Peter .
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2007, 2 :31-56
[107]   Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues [J].
Walden, Tomas B. ;
Hansen, Ida R. ;
Timmons, James A. ;
Cannon, Barbara ;
Nedergaard, Jan .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2012, 302 (01) :E19-E31
[108]   ACTIVATION OF GLUCOSE-TRANSPORT IN DIABETIC MUSCLE - RESPONSES TO CONTRACTION AND INSULIN [J].
WALLBERGHENRIKSSON, H ;
HOLLOSZY, JO .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 249 (03) :C233-C237
[109]   Neutral lipid bodies in prokaryotes:: Recent insights into structure, formation, and relationship to eukaryotic lipid depots [J].
Wältermann, M ;
Steinbüchel, A .
JOURNAL OF BACTERIOLOGY, 2005, 187 (11) :3607-3619
[110]   The life of lipid droplets [J].
Walther, Tobias C. ;
Farese, Robert V., Jr. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2009, 1791 (06) :459-466
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