WAT is a functional adipocyte?

被引：32

作者：

Church, Christopher D. ^{[1
]}

Horowitz, Mark C. ^{[2
]}

Rodeheffer, Matthew S. ^{[1
,3
,4
]}

机构：

[1] Yale Univ, Comparat Med Sect, New Haven, CT 06520 USA

[2] Yale Univ, Orthopaed & Rehabil, New Haven, CT 06520 USA

[3] Yale Univ, Dept Mol Cell & Dev Biol, New Haven, CT 06520 USA

[4] Yale Univ, Yale Stem Cell Ctr, New Haven, CT 06520 USA

来源：

ADIPOCYTE | 2012年 / 1卷 / 01期

关键词：

white adipose tissue; adipocyte; PPAR gamma; leptin; lipid; adiponectin;

D O I：

10.4161/adip.19132

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In vertebrates, adipose tissue is the main storage site for lipids within specialized lipid-laden mature adipocytes. While many species have evolved cells capable of lipid storage, the adipocyte represents a unique specialized cell involved in fuel storage, endocrine, nervous and immune function. However, the adipocytes are not the only cell type in mammals that can accumulate lipid droplets. The ectopic accumulation of lipid in non-adipose tissues including the liver, skeletal muscle, bone, pancreas, and heart in combination with its excessive accumulation in adipose tissue contributes to metabolic disease. Determining the lipid processing components that are necessary and sufficiently for lipid accumulation in adipose and non-adipose tissues, in addition to endocrine function, will lead to a clearer definition of an adipocyte.

引用

页码：38 / 45

页数：8

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