EFFECT OF THE SULFONYLUREA GLYBURIDE ON GLYCOGEN-SYNTHESIS IN ALLOXAN-INDUCED DIABETIC RAT HEPATOCYTES

被引：7

作者：

ATALAY, T

ALTAN, N

ONGUN, CO

ALAGOL, H

机构：

[1] GAZI UNIV,FAC MED,DEPT BIOCHEM,BESEVLER 06510,TURKEY

[2] ANKARA UNIV,FAC PHARM,DEPT PHARMACOL,BESEVLER 06510,TURKEY

来源：

GENERAL PHARMACOLOGY | 1994年 / 25卷 / 07期

关键词：

GLYBURIDE; GLYCOGEN; DIABETES MELLITUS;

D O I：

10.1016/0306-3623(94)90170-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effect of glyburide (glibenclamide) treatment on the liver glycogen levels of diabetic rats have been studied. 2. 3 weeks treatment with glyburide (5 mg/kg, orally) increased liver glycogen and decreased blood glucose levels. 3. The results of this study demonstrated that the sulfonylurea, glyburide is capable of exerting direct insulin-like effects on liver glycogen values in vivo.

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收藏

页码：1435 / 1437

页数：3

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