MONOCLONAL-ANTIBODY SPECIFIC FOR HISTO-BLOOD GROUP ANTIGENS-H (TYPE-2 AND TYPE-4) INTERFERES WITH LONG-TERM-MEMORY FORMATION IN RATS

被引：0
作者：
JORK, R
SMALLA, KH
KARSTEN, U
GRECKSCH, G
RUTHRICH, HL
MATTHIES, H
机构：
[1] CENT INST MOLEC BIOL,O-1115 BERLIN,GERMANY
[2] MED ACAD MAGDEBURG,INST PHARMACOL & TOXICOL,O-3090 MAGDEBURG,GERMANY
来源：
NEUROSCIENCE RESEARCH COMMUNICATIONS | 1991年 / 8卷 / 01期
关键词：
RAT; HIPPOCAMPUS; MEMORY FORMATION; GLYCOCONJUGATES-H TYPE-2; H-TYPE-4; HISTO-BLOOD GROUP ANTIGENS; FUCOSE;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
When rats were trained on a brightness discrimination task, pre- and posttrial intrahippocampal application of a monoclonal antibody (A46-B/B10, IgM) specific for blood group H (types 2 and 4) recognizing Fuc(--> 2)Gal-beta(1 --> 4)GlcNAc- and/or Fuc(1 --> 2)Gal-beta(1 --> 3) GalNAc-beta-, significantly impaired the retention performance of the animals in the relearning session. No interference with the learning performance was seen during training. The amnesic action of the antibody is discussed and a crucial role of particular fucosylated glycoconjugates in mechanisms underlying information processing and engram formation is suggested.
引用
收藏
页码：21 / 27
页数：7
相关论文
共 25 条
  • [1] STRUCTURE, BIOSYNTHESIS AND FUNCTIONS OF GLYCOPROTEIN GLYCANS
    BERGER, EG
    BUDDECKE, E
    KAMERLING, JP
    KOBATA, A
    PAULSON, JC
    VLIEGENTHART, JFG
    [J]. EXPERIENTIA, 1982, 38 (10): : 1129 - 1162
  • [2] 2-DEOXY-D-GALACTOSE IMPAIRS THE FUCOSYLATION OF GLYCOPROTEINS OF RAT-LIVER AND MORRIS HEPATOMA
    BUCHSEL, R
    HASSELSVISCHER, B
    TAUBER, R
    REUTTER, W
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1980, 111 (02): : 445 - 453
  • [3] EFFECTS OF THE AMNESIC AGENT 2-DEOXYGALACTOSE ON INCORPORATION OF FUCOSE INTO CHICK BRAIN GLYCOPROTEINS
    BULLOCK, S
    POTTER, J
    ROSE, SPR
    [J]. JOURNAL OF NEUROCHEMISTRY, 1990, 54 (01) : 135 - 142
  • [4] BULLOCK S, IN PRESS J NEUROCHEM
  • [5] SUBCELLULAR-LOCALIZATION OF INCREASED INCORPORATION OF [H-3]FUCOSE FOLLOWING PASSIVE-AVOIDANCE LEARNING IN THE CHICK
    BURGOYNE, RD
    ROSE, SPR
    [J]. NEUROSCIENCE LETTERS, 1980, 19 (03) : 343 - 348
  • [6] 2 MONOCLONAL-ANTIBODIES RECOGNIZING CARBOHYDRATE EPITOPES ON NEURAL ADHESION MOLECULES INTERFERE WITH CELL-INTERACTIONS
    FAHRIG, T
    SCHMITZ, B
    WEBER, D
    KUCHEREREHRET, A
    FAISSNER, A
    SCHACHNER, M
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1990, 2 (02) : 153 - 161
  • [7] JORK R, 1989, NEUROSCI RES COMMUN, V5, P3
  • [8] IMPAIRMENT OF GLYCOPROTEIN FUCOSYLATION IN RAT HIPPOCAMPUS AND THE CONSEQUENCES ON MEMORY FORMATION
    JORK, R
    GRECKSCH, G
    MATTHIES, H
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 25 (06) : 1137 - 1144
  • [9] JORK R, 1989, NEUROSCI RES COMMUN, V5, P102
  • [10] A NEW MONOCLONAL-ANTIBODY (A46-B/B10) HIGHLY SPECIFIC FOR THE BLOOD GROUP-H TYPE-2 EPITOPE - GENERATION, EPITOPE ANALYSIS, SEROLOGICAL AND HISTOLOGICAL-EVALUATION
    KARSTEN, U
    PILGRIM, G
    HANISCH, FG
    UHLENBRUCK, G
    KASPER, M
    STOSIEK, P
    PAPSDORF, G
    PASTERNAK, G
    [J]. BRITISH JOURNAL OF CANCER, 1988, 58 (02) : 176 - 181
123