IDENTIFICATION OF TYPE-SPECIFIC LINEAR EPITOPES IN THE GLYCOPROTEINS GP46 AND GP21 OF HUMAN T-CELL LEUKEMIA VIRUSES TYPE-I AND TYPE-II USING SYNTHETIC PEPTIDES

被引：97
作者：
HORAL, P
HALL, WW
SVENNERHOLM, B
LYCKE, J
JEANSSON, S
RYMO, L
KAPLAN, MH
VAHLNE, A
机构：
[1] GOTHENBURG UNIV,DEPT NEUROL,S-41346 GOTHENBURG,SWEDEN
[2] GOTHENBURG UNIV,DEPT MED BIOCHEM,S-41346 GOTHENBURG,SWEDEN
[3] CORNELL UNIV,N SHORE UNIV HOSP,COLL MED,DIV INFECT DIS,MANHASSET,NY 11030
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 13期
关键词：
SPECIFIC ANTIBODY DETECTION;
D O I：
10.1073/pnas.88.13.5754
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Synthetic peptides of 20-25 amino acids were employed in enzyme-linked immunosorbent assays to identify linear epitopes in the external glycoprotein gp46 and the transmembrane glycoprotein gp21 of human T-cell leukemia/lymphotropic viruses type I (HTLV-I) and II (HTLV-II). Ten linear epitopes were identified in the HTLV-I glycoproteins, seven in gp46 and three in gp21. Three major linear epitopes were identified in the gp46 or HTLV-II. Peptides representing linear epitopes of gp46 were found to be sensitive and specific for the detection of antibody and permit serological identification and differentiation of HTLV-I and HTLV-II infections.
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收藏
页码：5754 / 5758
页数：5
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