POTENTIAL CARDIOTONIC AGENTS .15. CRYSTAL MODIFICATIONS OF 3-CYANO-2-MORPHOLINO-5-(4-PYRIDINYL)PYRIDINE (AWD 122-14)

被引：0

作者：

HAGEN, V

RECK, G

DATHE, M

JANSCH, HJ

FEIST, M

机构：

[1] FORSCHUNGSINST MOLEK PHARMAKOL,BERLIN,GERMANY

[2] BUNDESANSTALT MAT PRUFUNG,BERLIN,GERMANY

[3] ARZNEIMITTELWERK DRESDEN GMBH,DRESDEN,GERMANY

[4] HUMBOLDT UNIV,O-1086 BERLIN,GERMANY

来源：

PHARMAZIE | 1992年 / 47卷 / 10期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation and X-ray crystallographic characterisation of 10 polymorphic or pseudo-polymorphic forms of the novel cardiotonic AWD 122-14 are described. Thermic transformations of some polymorphic forms into the alpha-form was proved by thermogravimetric analysis and powder diffraction pattern. In dissolution behaviour no significant differences were found between the crystalline modifications but with regard to galenic processing compact alpha-, gamma- and epsilon-forms show advantages.

引用

页码：777 / 780

页数：4

共 23 条

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