POTENTIAL CARDIOTONIC AGENTS .15. CRYSTAL MODIFICATIONS OF 3-CYANO-2-MORPHOLINO-5-(4-PYRIDINYL)PYRIDINE (AWD 122-14)

被引：0
|
作者：
HAGEN, V
RECK, G
DATHE, M
JANSCH, HJ
FEIST, M
机构：
[1] FORSCHUNGSINST MOLEK PHARMAKOL,BERLIN,GERMANY
[2] BUNDESANSTALT MAT PRUFUNG,BERLIN,GERMANY
[3] ARZNEIMITTELWERK DRESDEN GMBH,DRESDEN,GERMANY
[4] HUMBOLDT UNIV,O-1086 BERLIN,GERMANY
来源：
PHARMAZIE | 1992年 / 47卷 / 10期
关键词：
D O I：
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The preparation and X-ray crystallographic characterisation of 10 polymorphic or pseudo-polymorphic forms of the novel cardiotonic AWD 122-14 are described. Thermic transformations of some polymorphic forms into the alpha-form was proved by thermogravimetric analysis and powder diffraction pattern. In dissolution behaviour no significant differences were found between the crystalline modifications but with regard to galenic processing compact alpha-, gamma- and epsilon-forms show advantages.
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页码：777 / 780
页数：4
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