Recent advances of nanomaterials assisted negative ion laser desorption/ionization-time-of-flight mass spectrometry in the analysis of small molecules

被引：1

作者：

Zhang Xiaona ^{[1
]}

Niu Jiahua ^{[1
]}

Lu Minghua ^{[1
]}

Cai Zongwei ^{[2
]}

机构：

[1] Henan Univ, Coll Chem & Chem Engn, Kaifeng 475004, Peoples R China

[2] Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong 999077, Hong Kong, Peoples R China

来源：

CHINESE JOURNAL OF CHROMATOGRAPHY | 2016年 / 34卷 / 11期

基金：

中国国家自然科学基金;

关键词：

nanomaterials; laser desorption/ionization (LDI); time-of-flight mass spectrometry (TOF MS); small molecules; review;

D O I：

10.3724/SP.J.1123.2016.09014

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) is a soft ionization technique that has been widely used in the analysis of macromolecules, such as proteins, peptides, nucleic acids and polymers. However, it has difficulty in the analysis of small molecules with relative molecular masses below 700 Da because of the interferences from the matrix. To overcome these drawbacks, interference-free nanomaterials assisted laser desorption/ionization (LDI) has been paid more and more attention. Compared with the multiple peaks of one compound obtained in the positive ion mode, nanomaterials assisted negative ion LDI provides only deprotonated ion peak. In this article, recent advances of nanomaterials assisted negative ion LDI in the analysis of small molecules are reviewed.

引用

页码：1017 / 1021

页数：5

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