HUMAN RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN PEDIATRIC ONCOLOGY PRACTICE

被引：5
|
作者：
FERENCZ, T
CSAKI, C
SCHULER, D
BORSI, JD
机构：
[1] 2nd Department of Pediatrics, Semmelweis Medical School, Budapest
来源：
PEDIATRIC HEMATOLOGY AND ONCOLOGY | 1994年 / 11卷 / 02期
关键词：
HUMAN RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; NEUTROPENIA;
D O I：
10.3109/08880019409141657
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This paper reports preliminary experiences with human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) in children with malignant diseases administered for three indications: (1) chemotherapy-induced neutropenia and sepsis, (2) prolonged neutropenia decreasing dose intensity, and (3) prevention of neutropenia after sublethal doses of chemotherapy. It was concluded that in the daily dose of 5 mug/kg subcutaneously, GM-CSF is capable of reducing the duration of chemotherapy-induced neutropenia and may be an effective tool in maintaining dose intensity and achieving dose escalation.
引用
收藏
页码：201 / 205
页数：5
相关论文
共 50 条
  • [1] HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
    GASSON, JC
    NIMER, SD
    DIPERSIO, JF
    BALDWIN, GC
    WEISBART, RH
    GOLDE, DW
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, : 178 - 178
  • [2] RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR PRODUCES FEVER
    PETERS, WP
    SHOGAN, J
    SHPALL, EJ
    JONES, RB
    KIM, CS
    LANCET, 1988, 1 (8591): : 950 - 950
  • [3] CHEMOTACTIC ACTIVITY OF HUMAN RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
    WANG, JM
    COLELLA, S
    ALLAVENA, P
    MANTOVANI, A
    IMMUNOLOGY, 1987, 60 (03) : 439 - 444
  • [4] HUMAN RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR - A MULTILINEAGE HEMATOPOIETIN
    SIEFF, CA
    EMERSON, SG
    DONAHUE, RE
    NATHAN, DG
    WANG, EA
    WONG, GG
    CLARK, SC
    SCIENCE, 1985, 230 (4730) : 1171 - 1173
  • [5] CHARACTERIZATION OF PURIFIED RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
    GASSON, JC
    WEISBART, RH
    TOMONAGA, M
    GOLDE, DW
    EXPERIMENTAL HEMATOLOGY, 1985, 13 (05) : 424 - 424
  • [6] Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor
    Armitage, JO
    BLOOD, 1998, 92 (12) : 4491 - 4508
  • [7] Immunization with recombinant human granulocyte-macrophage colony-stimulating factor as a vaccine adjuvant elicits both a cellular and humoral response to recombinant human granulocyte-macrophage colony-stimulating factor
    McNeel, DG
    Schiffman, K
    Disis, ML
    BLOOD, 1999, 93 (08) : 2653 - 2659
  • [8] Safety of recombinant human granulocyte-macrophage colony-stimulating factor in healing pediatric severe burns
    Chi, Y. F.
    Chai, J. K.
    Luo, H. M.
    Zhang, Q. X.
    Feng, R.
    GENETICS AND MOLECULAR RESEARCH, 2015, 14 (01) : 2735 - 2741
  • [9] Comparison of recombinant granulocyte colony-stimulating factor, recombinant human granulocyte-macrophage colony-stimulating factor and placebo for treatment of septic preterm infants
    Ahmad, A
    Laborada, G
    Bussel, J
    Nesin, MJ
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2002, 21 (11) : 1061 - 1065
  • [10] RATIONALE FOR THE USE OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN ONCOLOGY
    AGLIETTA, M
    PIACIBELLO, W
    PASQUINO, P
    SANAVIO, F
    STACCHINI, A
    VOLTA, C
    MONTEVERDE, A
    FUBINI, L
    MORELLI, S
    SEVERINO, A
    SEMINARS IN ONCOLOGY, 1994, 21 (06) : 5 - 9
12345