ADENOSINE-A2 STIMULATION OF TYROSINE-HYDROXYLASE IN RAT STRIATAL MINCES IS REVERSED BY DOPAMINE-D2 AUTORECEPTOR ACTIVATION

被引：19

作者：

BOOTH, RG

BALDESSARINI, RJ

机构：

[1] MCLEAN HOSP,MAILMAN RES CTR,DEPT PSYCHIAT,PSYCHIAT RES LAB,115 MILL ST,BELMONT,MA 02178

[2] HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,NEUROSCI PROGRAM,BOSTON,MA 02115

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 185卷 / 2-3期

关键词：

Adenosine; Adenosine A[!sub]2[!/sub] receptors; Dopamine; Dopamine D[!sub]2[!/sub] autoreceptors; N-n-Propylnorapomorphine; Tyrosine hydroxylase;

D O I：

10.1016/0014-2999(90)90643-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The adenosine agonist, 2-chloroadenosine, stimulated tyrosine hydroxylase activity in rat striatal minces; this effect was attenuated by activation of dopamine (DA) D2 autoreceptors with N-n-propylnorapomorphine and antagonized by theopylline. Forskolin and 8-bromo-cAMP also increased tyrosine hydroxylase activity and their effects were not altered by 2-chloroadenosine. D1, α, β and 5-HT agonists did not affect tyrosine hydroxylase activity. Evidently, A2 receptors on DA nerve terminals stimulate striatal DA synthesis and this effect is negatively modulated by D2 autoreceptors, probably via changes in intracellular cAMP levels. © 1990.

引用

页码：217 / 221

页数：5

共 11 条

[1]

BOOTH RG, 1990, IN PRESS MOL PHARM

[2]

BRUNS RF, 1986, MOL PHARMACOL, V29, P331

[3]

HESS EJ, 1987, DOPAMINE RECEPTORS, P1

[4] CHANGE OF CYCLIC-AMP LEVEL IN SYNAPTOSOMES FROM CEREBRAL-CORTEX - INCREASE BY ADENOSINE DERIVATIVES [J].