2-AMINO-2-OXAZOLINES .5. SYNTHESIS OF SOME 5-DIALKYLAMINOMETHYL-2-AMINO-2-OXAZOLINES AND EVALUATION OF THEIR DIURETIC ACTIVITY

被引：4

作者：

DEMOTESMAINARD, F

TRANCHOT, J

CAMBAR, J

JARRY, C

机构：

[1] UNIV BORDEAUX 2,ETUD PHYSIOL & PHYSIOPATHOL RENALES GRP,F-33076 BORDEAUX,FRANCE

[2] UNIV BORDEAUX 2,CHIM PHYS LAB,F-33076 BORDEAUX,FRANCE

来源：

ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 04期

关键词：

D O I：

10.1002/ardp.19923250402

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 5-dialkylaminomethyl-2-amino-2-oxazolines was prepared and screened for diuretic activity. These compounds were previously examined for their lipophilic behaviour using a reversed-phase HPLC technique. The capacity factors, expressed as log k'w, were correlated with the partition coefficient log P. A QSAR analysis of the diuretic activity in relation with the lipophilicity was attempted for these structurally related compounds.

引用

页码：193 / 198

页数：6

共 14 条

[1] 2-AMINO-2-OXAZOLINES .2. REACTIVITY OF THE NITROGENS - CRYSTAL-STRUCTURES OF 2 ENDO EXO N-SUBSTITUTED COMPOUNDS [J].