Benzodiazepine Intoxication and Withdrawal: Assessment and Management

被引:2
作者
Galarneau, David W. [1 ]
Conrad, Erich J. [2 ]
机构
[1] Univ Queensland, Ochsner Hlth Syst, New Orleans, LA 70115 USA
[2] Louisiana State Univ, Sch Med, New Orleans, LA USA
关键词
Benzodiazepine; Intoxication; Tolerance; Withdrawal; Dependence; Addiction;
D O I
10.1016/j.ehmc.2015.06.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Benzodiazepines are one of the most commonly prescribed classes of medication. They also are commonly abused substances. In addition to their beneficial therapeutic effects, there are inherent risks with their use including abuse, dependence, intoxication, and withdrawal. It is crucial that all clinicians be well versed on the assessment and management of benzodiazepine intoxication and withdrawal. This article reviews these topics.
引用
收藏
页码:513 / 525
页数:13
相关论文
共 21 条
[1]   GUIDELINES FOR THE RATIONAL USE OF BENZODIAZEPINES - WHEN AND WHAT TO USE [J].
ASHTON, H .
DRUGS, 1994, 48 (01) :25-40
[2]   PROTRACTED WITHDRAWAL SYNDROMES FROM BENZODIAZEPINES [J].
ASHTON, H .
JOURNAL OF SUBSTANCE ABUSE TREATMENT, 1991, 8 (1-2) :19-28
[3]  
Billioti de Gage S, 2014, BMJ, V349
[4]  
Brady ST, 2012, BASIC NEUROCHEMISTRY: PRINCIPLES OF MOLECULAR, CELLULAR, AND MEDICAL NEUROBIOLOGY, 8THEDITION, P1
[5]   The 'ABC' of GABA receptors: A brief review [J].
Chebib, M ;
Johnston, GAR .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1999, 26 (11) :937-940
[6]   Safety of benzodiazepines and opioids in very severe respiratory disease: national prospective study [J].
Ekstrom, Magnus P. ;
Bornefalk-Hermansson, Anna ;
Abernethy, Amy P. ;
Currow, David C. .
BMJ-BRITISH MEDICAL JOURNAL, 2014, 348
[7]  
GREENBLATT DJ, 1977, CLIN PHARMACOL THER, V21, P497
[8]   Quality of life in a cohort of high-dose benzodiazepine dependent patients [J].
Lugoboni, Fabio ;
Mirijello, Antonio ;
Faccini, Marco ;
Casari, Rebecca ;
Cossari, Anthony ;
Musi, Gessica ;
Bissoli, Giorgia ;
Quaglio, Gianluca ;
Addolorato, Giovanni .
DRUG AND ALCOHOL DEPENDENCE, 2014, 142 :105-109
[9]  
MACDONALD RL, 1994, ANNU REV NEUROSCI, V17, P569, DOI 10.1146/annurev.neuro.17.1.569
[10]  
Pages KP, 1998, AM J ADDICTION, V7, P198