SYNTHESIS OF SOME NEW CONDENSED PYRIMIDINES - THIENOPTERIDINE AND PURINE DERIVATIVES

被引：0
|
作者：
ELFARARGY, AF
ASSY, MG
HASSANIEN, MM
机构：
来源：
PHARMAZIE | 1993年 / 48卷 / 02期
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
7-Hydroxypteridine (3) and its isomeric 6-hydroxypteridine (4) were prepared by condensation of 5,6-diaminouracil (1) with ethyl thienoylpyruvate (2) in pyridine and hydrochloric acid, respectively. Compounds 3 and 4 were converted into the corresponding thienopteridines 8 and 9 upon treatment with phosphorus pentasulphide. The synthesis of pteridines 12 and 13 was achieved from nitrosouracil (10). Also, the purine 15 and condensed purine 18 were prepared.
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页码：109 / 111
页数：3
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