STEPWISE REGENERATION AND RECOVERY OF DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITE MONOMERS DURING SOLID-PHASE OLIGONUCLEOTIDE SYNTHESIS

被引：20
作者：
SCREMIN, CL
ZHOU, L
SRINIVASACHAR, K
BEAUCAGE, SL
机构：
[1] US FDA,CTR BIOL EVALUAT & RES,DIV HEMATOL PROD,BETHESDA,MD 20892
[2] US FDA,CTR DRUG EVALUAT & RES,DIV METAB & ENDOCRINE DRUG PROD,ROCKVILLE,MD 20857
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 08期
关键词：
D O I：
10.1021/jo00087a005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Deoxyribonucleoside phosphoramidites 1a-d have been regenerated, in a stepwise manner, during solid-phase oligonucleotide synthesis and have been efficiently reutilized in the solid-phase synthesis of polydeoxyribonucleotides. The activator 1H-tetrazole has also been recovered and recycled.
引用
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页码：1963 / 1966
页数：4
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