IMMUNE SENESCENCE - MECHANISMS AND CLINICAL IMPLICATIONS

被引:65
作者
BENYEHUDA, A [1 ]
WEKSLER, ME [1 ]
机构
[1] CORNELL UNIV, MED CTR, COLL MED, DIV GERIAT & GERONTOL, NEW YORK, NY 10021 USA
关键词
D O I
10.3109/07357909209024815
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:525 / 531
页数:7
相关论文
共 50 条
[1]   REDUCED INVITRO RESPONSE TO CONCANAVALIN-A AND LIPOPOLYSACCHARIDE IN SENESCENT MICE - FUNCTION OF REDUCED NUMBER OF RESPONDING CELLS [J].
ABRAHAM, C ;
TAL, Y ;
GERSHON, H .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1977, 7 (05) :301-304
[2]  
BANGS LA, 1991, J IMMUNOL, V146, P1996
[3]   AGE-RELATED DECREMENT IN CYTOTOXIC LYMPHOCYTE-T (CTL) ACTIVITY IS ASSOCIATED WITH DECREASED LEVELS OF MESSENGER-RNA ENCODED BY 2 CTL-ASSOCIATED SERINE ESTERASE GENES AND THE PERFORIN GENE IN MICE [J].
BLOOM, ET ;
UMEHARA, H ;
BLEACKLEY, RC ;
OKUMURA, K ;
MOSTOWSKI, H ;
BABBITT, JT .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (10) :2309-2316
[4]   CROSS-WIRING OF THE IMMUNE-RESPONSE IN OLD MICE - INCREASED AUTOANTIBODY RESPONSE DESPITE REDUCED ANTIBODY-RESPONSE TO NOMINAL ANTIGEN [J].
BOVBJERG, DH ;
KIM, YT ;
SCHWAB, R ;
SCHMITT, K ;
DEBLASIO, T ;
WEKSLER, ME .
CELLULAR IMMUNOLOGY, 1991, 135 (02) :519-525
[5]   SECRETORY IMMUNOGLOBULIN-A ANTIBODY-RESPONSE IS CONSERVED IN AGED MICE FOLLOWING ORAL IMMUNIZATION WITH INFLUENZA-VIRUS VACCINE [J].
CHEN, KS ;
QUINNAN, GV .
JOURNAL OF GENERAL VIROLOGY, 1989, 70 :3291-3296
[6]   AGE-RELATED-CHANGES IN HUMAN-LYMPHOCYTE SUBSETS - PROGRESSIVE REDUCTION OF THE CD4 CD45R (SUPPRESSOR INDUCER) POPULATION [J].
DEPAOLI, P ;
BATTISTIN, S ;
SANTINI, GF .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1988, 48 (03) :290-296
[7]  
EFFROS RB, 1987, AGING IMMUNE RESPONS, P45
[8]   IMMUNOLOGICAL STUDIES OF AGING - DECREASED PRODUCTION OF AND RESPONSE TO T-CELL GROWTH-FACTOR BY LYMPHOCYTES FROM AGED HUMANS [J].
GILLIS, S ;
KOZAK, R ;
DURANTE, M ;
WEKSLER, ME .
JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (04) :937-942
[9]   SENSITIVITY OF LYMPHOCYTES TO PROSTAGLANDIN-E2 INCREASES IN SUBJECTS OVER AGE 70 [J].
GOODWIN, JS ;
MESSNER, RP .
JOURNAL OF CLINICAL INVESTIGATION, 1979, 64 (02) :434-439
[10]  
GOTTESMAN SRS, 1988, J IMMUNOL, V140, P1783