STRUCTURE AND VARIABILITY OF RECENTLY INSERTED ALU FAMILY MEMBERS

被引：177

作者：

BATZER, MA ^{[1
]}

KILROY, GE ^{[1
]}

RICHARD, PE ^{[1
]}

SHAIKH, TH ^{[1
]}

DESSELLE, TD ^{[1
]}

HOPPENS, CL ^{[1
]}

DEININGER, PL ^{[1
]}

机构：

[1] ALTON OCHSNER MED FDN & OCHSNER CLIN,MOLEC GENET LAB,NEW ORLEANS,LA 70121

来源：

NUCLEIC ACIDS RESEARCH | 1990年 / 18卷 / 23期

关键词：

D O I：

10.1093/nar/18.23.6793

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The HS subfamily of Alu sequences is comprised of a group of nearly identical members. Individual subfamily members share 97.7% nucleotide identity with each other and 98.9% nucleotide identity with the HS consensus sequence. Individual subfamily members are on the average 2.8 million years old, and were probably derived from a single source 'master' gene sometime after the human/great ape divergence. The recent Alu family member insertions provide a better image of the structure of Alu retroposons before they have had the opportunity to change significantly. All of the HS subfamily members are flanked by perfect direct repeats as a result of insertion at staggered nicks. The 'master' gene from which the HS subfamily members were derived had an oligo-dA rich tail at least 40 bases long. The 'master' gene is very rich in CpG dinucleotides, but nucleotide substitutions within subfamily members accumulated in a random manner typical for Alu sequences with CpG substitutions occurring 9.2 fold faster than non-CpG substitutions.

引用

页码：6793 / 6798

页数：6

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