Hematologic Malignancies in Children with Down Syndrome: Transient Myeloproliferative Disease and Acute Megakaryoblastic Leukemia

被引:0
作者
Atik, Tahir [1 ]
Sivis, Zuhal Onder [1 ]
Karadas, Nihal [1 ]
Rashnonejad, Afrooz [2 ,3 ]
Atikan, Basak Yildiz [1 ]
Karapinar, Deniz Yilmaz [1 ]
Vardar, Fadil [1 ]
Cogulu, Ozgur [1 ]
Ozkinay, Ferda [1 ]
机构
[1] Ege Univ, Tip Fak, Cocuk Sagligi & Hastaliklari Anabilim Dali, Izmir, Turkey
[2] Ege Univ, Fen Bilimleri Enstitusu, Bioteknoloji Anabilim Dali, Izmir, Turkey
[3] Islamic Azad Univ, Genc Arastiricilar & Seckinler Kulubu Kuzey Tahra, Tahran, Iran
关键词
Down syndrome; myeloproliferative disease; acute megakaryoblastic leukemia; acute lymphoblastic leukemia;
D O I
10.4274/jpr.27146
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Down Syndrome (DS) is an important genetic disease resulting from partial or total trisomy of chromosome 21 and characterized by dysmorphic facial features, intellectual disabilities and multiple congenital anomalies. Children with DS are at increased risk of developing leukemia. Specifically, 3-10% of newborns with DS are diagnosed with transient myeloproliferative disease, and children with DS are 500 times more likely to develop acute megakaryoblastic leukemia (AMKL), and 20 times more likely to develop acute lymphoblastic leukemia (ALL) than children without DS. In this study, we report two children with DS presented with transient myeloproliferative disease.
引用
收藏
页码:46 / 48
页数:3
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