Role of maspin in cancer

被引:93
作者
Berardi, Rossana [1 ]
Morgese, Francesca [1 ]
Onofri, Azzurra [1 ]
Mazzanti, Paola [1 ]
Pistelli, Mirco [1 ]
Ballatore, Zelmira [1 ]
Savini, Agnese [1 ]
De Lisa, Mariagrazia [1 ]
Caramanti, Miriam [1 ]
Rinaldi, Silvia [1 ]
Pagliaretta, Silvia [1 ]
Santoni, Matteo [1 ]
Pierantoni, Chiara [1 ]
Cascinu, Stefano [1 ]
机构
[1] Univ Politecn Marche, Azienda Osped Univ Osped Riuniti Umberto 1, Med Oncol Unit, GM Lancisi, Via Conca, I-7160126 Ancona, Italy
关键词
Maspin; Serine protease; Prognosis;
D O I
10.1186/2001-1326-2-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Maspin (mammary serine protease inhibitor), is a member of the serine protease inhibitor/non-inhibitor superfamily. Its expression is down-regulated in breast, prostate, gastric and melanoma cancers but over-expressed in pancreatic, gallbladder, colorectal, and thyroid cancers suggesting that maspin may play different activities in different cell types. However, maspin expression seems to be correlated with better prognosis in prostate, bladder, lung, gastric, colorectal, head and neck, thyroid and melanoma cancer. In breast and ovarian cancer maspin significance is associated with its subcellular localization: nucleus maspin expression correlates with a good prognosis, whilst in pancreatic cancer it predicts a poor prognosis. Since tumor metastasis requires the detachment and invasion of tumor cells through the basement membrane and stroma, a selectively increased adhesion by the presence of maspin may contribute to the inhibition of tumor metastasis. Furthermore the different position of maspin inside the cell or its epigenetic modifications may explain the different behavior of the expression of maspin between tumors. The expression of maspin might be useful as a prognostic and possibly predictive factor for patients with particular types of cancer and data can guide physicians in selecting therapy. Its expression in circulating tumor cells especially in breast cancer, could be also useful in clinical practice along with other factors, such as age, comorbidities, blood examinations in order to select the best therapy to be carried out. Focusing on the malignancies in which maspin showed a positive prognostic value, therapeutic approaches studied so far aimed to re-activate a dormant tumor suppressor gene by designed transcription factors, to hit the system that inhibits the expression of maspin, to identify natural substances that can determine the activation and the expression of maspin or possible "molecules binds" to introduce maspin in cancer cell and gene therapy capable of up-regulating the maspin in an attempt to reduce primarily the risk of metastasis. Further studies in these directions are necessary to better define the therapeutic implication of maspin.
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页数:19
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共 160 条
[61]   Maspin overexpression correlates with positive response to primary chemotherapy in ovarian cancer patients [J].
Klasa-Mazurkiewicz, Dagmara ;
Narkiewicz, Joanna ;
Milczek, Tomasz ;
Lipinska, Barbara ;
Ernerich, Janusz .
GYNECOLOGIC ONCOLOGY, 2009, 113 (01) :91-98
[62]   Maspin protein expression correlates with tumor progression in non-muscle invasive bladder cancer [J].
Kramer, Mario W. ;
Waalkes, Sandra ;
Hennenlotter, Jorg ;
Serth, Jurgen ;
Stenzl, Arnulf ;
Kuczyk, Markus A. ;
Merseburger, Axel S. .
ONCOLOGY LETTERS, 2010, 1 (04) :621-626
[63]   Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition [J].
Latha, K ;
Zhang, WG ;
Cella, N ;
Shi, HY ;
Zhang, M .
MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (05) :1737-1748
[64]   The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix [J].
Law, RHP ;
Irving, JA ;
Buckle, AM ;
Ruzyla, K ;
Buzza, M ;
Bashtannyk-Puhalovich, TA ;
Beddoe, TC ;
Nguyen, K ;
Worrall, DM ;
Bottomley, SP ;
Bird, PI ;
Rossjohn, J ;
Whisstock, JC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (23) :22356-22364
[65]  
Lee DY, 2008, APPL IMMUNOHISTO M M, V16, P13
[66]   Clinicopathological significance of maspin expression in breast cancer [J].
Lee, MJ ;
Suh, CH ;
Li, ZH .
JOURNAL OF KOREAN MEDICAL SCIENCE, 2006, 21 (02) :309-314
[67]   Detection of breast cancer cell contamination in leukapheresis product by real-time quantitative polymerase chain reaction [J].
Leone, F ;
Perissinotto, E ;
Viale, A ;
Cavalloni, G ;
Taraglio, S ;
Capaldi, A ;
Piacibello, W ;
Torchio, B ;
Aglietta, M .
BONE MARROW TRANSPLANTATION, 2001, 27 (05) :517-523
[68]   Maspin expression in oral squamous cell carcinoma [J].
Lezzi, Giovanna ;
Piattelli, Adriano ;
Rubini, Corrado ;
Goteri, Gaia ;
Artese, Luciano ;
Perrotti, Vittoria ;
Carinci, Francesco .
JOURNAL OF CRANIOFACIAL SURGERY, 2007, 18 (05) :1039-1043
[69]   Targeted expression of maspin in tumor vasculatures induces endothelial cell apoptosis [J].
Li, ZG ;
Shi, HY ;
Zhang, M .
ONCOGENE, 2005, 24 (12) :2008-2019
[70]  
Lin Z, 2002, CLIN CANCER RES, V8, P2924