METHOTREXATE FOR THE TREATMENT OF SEVERE MUCOCUTANEOUS LUPUS-ERYTHEMATOSUS

被引：24

作者：

BOTTOMLEY, WW

GOODFIELD, M

机构：

[1] Department of Dermatology, Leeds General Infirmary, Leeds LS1 3EX, Great George Street

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1995年 / 133卷 / 02期

关键词：

D O I：

10.1111/j.1365-2133.1995.tb02637.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report three women with severe, chronic mucocutaneous lupus erythematosus who showed a significant improvement during oral methotrexate therapy; the improvement was sustained after the drug was discontinued. Their disease had previously been refractory to a wide range of conventional systemic immunosuppressive therapies. Other treatments were progressively withdrawn, and control was maintained, for a variable length of time, with methotrexate alone, or with a small dose of prednisolone.

引用

页码：311 / 314

页数：4

共 12 条

[1] ALARCON GS, 1990, ARTHRITIS RHEUM, V33, P1156
[2] CHANG DM, 1992, J RHEUMATOL, V19, P1678
[3] GARCIA MG, 1993, MED CLIN-BARCELONA, V101, P361
[4] HUGHES GRV, 1994, J ROY COLL PHYS LOND, V28, P260
[5] MIESCHER P A, 1965, Semin Hematol, V2, P1
[6] NORRIS DA, 1977, J LAB CLIN MED, V90, P569
[7] THE USE OF METHOTREXATE IN STEROID-RESISTANT SYSTEMIC LUPUS-ERYTHEMATOSUS
ROTHENBERG, RJ
GRAZIANO, FM
GRANDONE, JT
GOLDBERG, JW
BJARNASON, DF
FINESILVER, AG
[J]. ARTHRITIS AND RHEUMATISM, 1988, 31 (05): : 612 - 615
[8] SPERLING RI, 1990, ARTHRITIS RHEUM, V33, P1149
[9] SPECIAL ARTICLE - THE 1982 REVISED CRITERIA FOR THE CLASSIFICATION OF SYSTEMIC LUPUS-ERYTHEMATOSUS
TAN, EM
COHEN, AS
FRIES, JF
MASI, AT
MCSHANE, DJ
ROTHFIELD, NF
SCHALLER, JG
TALAL, N
WINCHESTER, RJ
[J]. ARTHRITIS AND RHEUMATISM, 1982, 25 (11): : 1271 - 1277
[10] LONG-TERM PROSPECTIVE-STUDY OF METHOTREXATE IN THE TREATMENT OF RHEUMATOID-ARTHRITIS - 84-MONTH UPDATE
WEINBLATT, ME
WEISSMAN, BN
HOLDSWORTH, DE
FRASER, PA
MAIER, AL
FALCHUK, KR
COBLYN, JS
[J]. ARTHRITIS AND RHEUMATISM, 1992, 35 (02): : 129 - 137

← 1 2 →