TRICYCLIC CEPHEMS AS INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE - THIENO[3,4-C]CEPHAM SULFONES AND PYRROLO[3,4-C]CEPHAM SULFONES

被引：2
作者：
ALPEGIANI, M
BISSOLINO, P
CORIGLI, R
RIZZO, V
PERRONE, E
机构：
[1] Pharmacia Farmitalia Carlo Erba S.r.l., 20014 Nerviano, Milano
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 07期
关键词：
D O I：
10.1016/0960-894X(95)00095-B
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Thieno- and pyrrolo[3,4-c]cepham sulfones were synthesized and compared to their furo analogs for activity as human leukocyte elastase inhibitors, Pyrrolo derivatives, especially when N-alkylated, combined excellent hydrolytic stability with remarkable inhibitory activity.
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收藏
页码：691 / 694
页数：4
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