LIPID-PEROXIDATION AND PLATELET MEMBRANE FLUIDITY - IMPLICATIONS FOR ALZHEIMERS-DISEASE

被引：25
作者：
VANRENSBURG, SJ
DANIELS, WMU
VANZYL, J
POTOCNIK, FCV
VANDERWALT, BJ
TALJAARD, JJF
机构：
[1] UNIV STELLENBOSCH,TYGERBERG HOSP,TYGERBERG 7505,SOUTH AFRICA
[2] UNIV STELLENBOSCH,SCH MED,DEPT PHARMACOL,TYGERBERG 7505,SOUTH AFRICA
[3] UNIV STELLENBOSCH,SCH MED,DEPT PSYCHIAT,TYGERBERG 7505,SOUTH AFRICA
来源：
NEUROREPORT | 1994年 / 5卷 / 17期
关键词：
ALZHEIMERS DISEASE; PLATELET MEMBRANE FLUIDITY; LIPID PEROXIDATION; FREE RADICALS; ASCORBATE; CHOLESTEROL; APOLIPOPROTEIN E;
D O I：
10.1097/00001756-199411000-00004
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
IN humans, the fluidity of cell membranes generally decreases with age. Unexpectedly, several laboratories have found increased fluidity of platelet membranes (mainly endoplasmic reticulum) in patients with Alzheimer's disease (AD) compared with controls. In the present study, free radical induced lipid peroxidation was found to increase the fluidity of platelet membranes. Hydroxyl radicals were generated in the presence of Fe2+ and EDTA at low concentrations of ascorbate. It is hypothesised that platelet membranes are unable to restore their microviscosity by incorporating cholesterol. There may be a link between the result obtained in this study, the recently discovered decreased cholesterol content of affected AD neuronal membranes, and the increased frequency of epsilon 4 apolipoprotein E (a cholesterol carrier) found in AD patients.
引用
收藏
页码：2221 / 2224
页数：4
相关论文
共 25 条
[1]   AMINO-ACID-CONCENTRATIONS IN CEREBROSPINAL-FLUID AND PLASMA IN ALZHEIMERS-DISEASE AND HEALTHY CONTROL SUBJECTS [J].
BASUN, H ;
FORSSELL, LG ;
ALMKVIST, O ;
COWBURN, RF ;
EKLOF, R ;
WINBLAD, B ;
WETTERBERG, L .
JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION, 1990, 2 (04) :295-304
[2]   PH AND THE RECYCLING OF TRANSFERRIN DURING RECEPTOR-MEDIATED ENDOCYTOSIS [J].
DAUTRYVARSAT, A ;
CIECHANOVER, A ;
LODISH, HF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (08) :2258-2262
[3]  
FINEAN JB, 1978, MEMBRANES THEIR CELL, P30
[4]   IRON ASCORBATE-INDUCED LIPID-PEROXIDATION CHANGES MEMBRANE FLUIDITY AND MUSCARINIC CHOLINERGIC RECEPTOR-BINDING IN RAT FRONTAL-CORTEX [J].
GHOSH, C ;
DICK, RM ;
ALI, SF .
NEUROCHEMISTRY INTERNATIONAL, 1993, 23 (05) :479-484
[5]   ALUMINUM SALTS ACCELERATE PEROXIDATION OF MEMBRANE-LIPIDS STIMULATED BY IRON SALTS [J].
GUTTERIDGE, JMC ;
QUINLAN, GJ ;
CLARK, I ;
HALLIWELL, B .
BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 835 (03) :441-447
[6]   OXYGEN RADICALS AND THE NERVOUS-SYSTEM [J].
HALLIWELL, B ;
GUTTERIDGE, JMC .
TRENDS IN NEUROSCIENCES, 1985, 8 (01) :22-26
[7]   PROGRAMMED LIPID-PEROXIDATION OF BIOMEMBRANES GENERATING KINKED PHOSPHOLIPIDS PERMITTING LOCAL MOLECULAR MOBILITY - A PEROXIDATIVE THEORY OF FLUIDITY MANAGEMENT [J].
JAIN, S ;
THOMAS, M ;
KUMAR, GP ;
LALORAYA, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 195 (02) :574-580
[8]   PLATELET MEMBRANE FLUIDITY AND PLASMA MALONDIALDEHYDE LEVELS IN ALZHEIMERS DEMENTED PATIENTS WITH AND WITHOUT FAMILY HISTORY OF DEMENTIA [J].
KALMAN, J ;
DEY, I ;
ILONA, SV ;
MATKOVICS, B ;
BROWN, D ;
JANKA, Z ;
FARKAS, T ;
JOO, F .
BIOLOGICAL PSYCHIATRY, 1994, 35 (03) :190-194
[9]   INVIVO MODULATION OF BRAIN CHOLESTEROL LEVEL AND LEARNING-PERFORMANCE BY A NOVEL PLANT LIPID - INDICATIONS FOR INTERACTIONS BETWEEN HIPPOCAMPAL-CORTICAL CHOLESTEROL AND LEARNING [J].
KESSLER, AR ;
KESSLER, B ;
YEHUDA, S .
LIFE SCIENCES, 1986, 38 (13) :1185-1192
[10]   FOLATE, VITAMIN-B12 AND COGNITIVE IMPAIRMENT IN PATIENTS WITH ALZHEIMERS-DISEASE [J].
LEVITT, AJ ;
KARLINSKY, H .
ACTA PSYCHIATRICA SCANDINAVICA, 1992, 86 (04) :301-305
123