A SIMPLE AND HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF A 1-BETA-METHYLCARBAPENEM KEY INTERMEDIATE BY DEALLYLOXYCARBONYLATION USING PALLADIUM COMPLEXES

被引：26

作者：

MURAYAMA, T ^{[1
]}

YOSHIDA, A ^{[1
]}

KOBAYASHI, T ^{[1
]}

MIURA, T ^{[1
]}

机构：

[1] TAKASAGO INT CORP,CENT RES LAB,HIRATSUKA 254,KANAGAWA,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 15期

关键词：

D O I：

10.1016/0040-4039(94)85196-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Simple, highly diastereoselective synthesis of the key 1 beta-methylcarbapenem intermediate 1 has been accomplished via a palladium catalyzed deallyloxycarbonylation of diallyl malonate derivative 4a which was readily prepared from (3S,4R)-4-acetoxy-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-2-azetidimone 2 in two steps.

引用

页码：2271 / 2274

页数：4

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