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CEN Grenoble, Dept Biol Mol & Struct Biochim & Biophys Syst Int, Lab Biochim & Biophys Syst Integres, CEA,UMR 314, F-38054 Grenoble 9, France CEN Grenoble, Dept Biol Mol & Struct Biochim & Biophys Syst Int, Lab Biochim & Biophys Syst Integres, CEA,UMR 314, F-38054 Grenoble 9, France