Activity of Platelets' Aggregation in Patients of The Second Mature Age with Arterial Hypertension of The 3rddegree.

The aim is to determine the activity level of platelets' aggregation and separate mechanisms of its inhibition in patients with arterial hypertension of the 3rd degree. Under observation there were 42 patients with arterial hypertension of the 3rd degree, risk 4, including 22 men and 20 women of the second mature age. The control group was composed of 25 clinically healthy people of the same age. There were applied biochemical, hematological and statistical methods of investigation. The blood of patients was noted to have the increase of hromboxane B2 by 60.4% at lowering of 6-keto-prostaglandin F-1 alpha by 11.9% and quantity depression of nitric oxide summary metabolites by 16.7%. The degree of aggregation and the index of platelets' aggregation with collagen surpassed in patients the control level by 20.0% and by 23.2%, with ristomicin they were higher the control values by 21.6% and by 39.6%, with ADP - by 16.9% and by 25.0%, respectively. The patients were found to have the decrease of platelets-discocytes till 57.8 +/- 0.27%. The sum of platelets' active forms in their blood reached 42.2 +/- 0.17% (the control value -17.9 +/- 0.09%) at the content of small and large aggregates 14.5 +/- 0.09 and 4.1 +/- 0.12 (the control values -2.9 +/- 0.06 and 0.2 +/- 0.06 on 100 freely lying platelets). Existing in the examined patients surplus platelets' activity has in its basis the rise of adhesive and aggregative activity of platelets at weakening of their capability to disaggregation. Arterial hypertension and strengthening of lipids' peroxidation in plasma should be considered the most significant causal factors of the detected thrombocytopathy.