SYNTHESIS AND SOME REACTIONS OF THIENO[2,3-C]PYRIDAZINE DERIVATIVES AND THEIR ANTIBACTERIAL ACTIVITY

被引：19

作者：

ABBADY, MS

RADWAN, SM

机构：

[1] Chemistry Department, Faculty of Science, Assiut University, Assiut

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1994年 / 86卷 / 1-4期

关键词：

SYNTHESIS; THIENOPYRIDAZINE; IMIDAZOLOTHIENOPYRIDAZINE; PYRIDAZINOTHIENOOXAZINE; PYRIDAZINOTHIENOPYRIMIDINE;

D O I：

10.1080/10426509408018405

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The title compounds (4a-f) were prepared by S-alkylation of 4-cyano-5,6-difur-2'-yl-2H-pyridazine-3-thione (2) and subsequent cyclization in ethanol in the presence of potassium carbonate. Reaction of o-disubstituted thienopyridazines (4a-d) with different reagents afforded tricyclic compounds namely, imidazothienopyridazine (5), pyridazinothienooxazine (6) and pyridazinothienopyrimidines (7-9). Most of the prepared compounds exhibited pronounced antibacterial activity.

引用

页码：203 / 209

页数：7

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