NOVEL PROCEDURE FOR THE PREPARATION OF 1-ALPHA,3-BETA-DIHYDROXY-2-BETA-TRITIATED STEROIDAL COMPOUNDS

被引:11
作者
WATANABE, H
KAWANISHI, T
MIYAMOTO, K
KUBODERA, N
SASAHARA, K
OCHI, K
机构
[1] CHUGAI PHARMACEUT CO LTD,EXPLORATORY RES LABS,1-135 KOMAKADO,GOTEMBA,SHIZUOKA 412,JAPAN
[2] CHUGAI PHARMACEUT CO LTD,PROD TECHNOL RES LABS,KITAKU,TOKYO,JAPAN
关键词
STEROIDS; 1-ALPHA; 3-BETA-DIHYDROXY-2-BETA-TRITIATED STEROIDAL COMPOUND; SODIUM BOROTRITIIDE; 22-OXACALCITRIOL;
D O I
10.1016/0039-128X(92)90098-T
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A novel procedure for the preparation of 1-alpha,3-beta-dihydroxy-2-beta-tritiated steroidal compounds by the reduction of the alpha-epoxide with sodium borotritiide in diglyme at 80 C is described.
引用
收藏
页码:444 / 446
页数:3
相关论文
共 8 条
  • [1] 12-OXYGENATED PREGNANE DERIVATIVES .1. (A) 21-ACETOXY-12-ALPHA-17-ALPHA-DIHYDROXYPREGN-4-ENE-3-20-DIONE - (B) 12-ALPHA-21-DIACETOXY-17-ALPHA-HYDROXYPREGN-4-ENE-3-20-DIONE - (C) 3-ALPHA-12-ALPHA-21-TRIACETOXY-17-ALPHA-HYDROXY-PREGNAN-20-ONE - AND (D) MISCELLANEOUS OBSERVATIONS
    ADAMS, WJ
    PATEL, DK
    PETROW, V
    STUARTWEBB, IA
    [J]. JOURNAL OF THE CHEMICAL SOCIETY, 1954, (JUN): : 1825 - 1836
  • [2] PREPARATION AND USE OF LIET3BT AND LIALT4 AT MAXIMUM SPECIFIC ACTIVITY
    ANDRES, H
    MORIMOTO, H
    WILLIAMS, PG
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (08) : 627 - 628
  • [3] DIE UBERFUHRUNG VON MARINOBUFAGIN IN TELOCINOBUFAGIN - UBER KROTENGIFTE .19.
    BHARUCHA, M
    JAGER, H
    MEYER, K
    REICHSTEIN, T
    SCHINDLER, O
    [J]. HELVETICA CHIMICA ACTA, 1959, 42 (05) : 1395 - 1398
  • [4] THE NONCALCEMIC ANALOG OF VITAMIN-D, 22-OXACALCITRIOL, SUPPRESSES PARATHYROID-HORMONE SYNTHESIS AND SECRETION
    BROWN, AJ
    RITTER, CR
    FINCH, JL
    MORRISSEY, J
    MARTIN, KJ
    MURAYAMA, E
    NISHII, Y
    SLATOPOLSKY, E
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (03) : 728 - 732
  • [5] MIYAMOTO K, 1986, Patent No. 267549
  • [6] SYNTHETIC STUDIES OF VITAMIN-D3 ANALOGS FROM BILE-ACIDS .3. SYNTHESES OF 1-ALPHA,25-, 1-ALPHA,24R-, AND 1-ALPHA,24S-DIHYDROXYCHOLECALCIFEROLS FROM LITHOCHOLIC ACID AND THEIR BIOLOGICAL-ACTIVITIES
    OCHI, K
    MATSUNAGA, I
    NAGANO, H
    FUKUSHIMA, M
    SHINDO, M
    KANEKO, C
    ISHIKAWA, M
    DELUCA, HF
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1979, (01): : 165 - 169
  • [7] A NOVEL PROCEDURE FOR THE REDUCTION OF EPOXIDES WITH SODIUM-BOROHYDRIDE
    SOAI, K
    OOKAWA, A
    OYAMADA, H
    TAKASE, M
    [J]. HETEROCYCLES, 1982, 19 (08) : 1371 - 1374
  • [8] CLEAVAGE OF EPOXIDE RING IN TRANS-EPOXY-ALCOHOLS BY SODIUM BORO-HYDRIDE IN METHANOL
    WEISSENBERG, M
    KRINSKY, P
    GLOTTER, E
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1978, (06): : 565 - 568