DISTRIBUTION OF POLYMORPHIC GENE DUPLICATION AT THE GPDH LOCUS IN NATURAL-POPULATIONS OF DROSOPHILA-MELANOGASTER

被引：0
作者：
KOGA, A
BABA, H
KUSAKABE, S
HATTORI, M
MUKAI, T
机构：
[1] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN
[2] KYUSHU UNIV,GENET INFORMAT RES LAB,FUKUOKA 812,JAPAN
来源：
JOURNAL OF MOLECULAR EVOLUTION | 1993年 / 36卷 / 06期
关键词：
GENE DUPLICATION; GPDH GENE; POLYMORPHISM; DROSOPHILA-MELANOGASTER;
D O I：
10.1007/BF00556357
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The glycerol-3-phosphate dehydrogenase (GPDH, E.C. 1.1.1.8) gene of Drosophila melanogaster contains a tandem duplication of a 4.5-kb-long DNA fragment. Survey of the Gpdh gene region by the Southern blot analysis revealed the following features of this gene duplication: (1) The duplication was not observed in chromosome lines that carry In(2L)t, a cosmopolitan chromosomal inversion in this species. The duplication and the inversion are in linkage disequilibrium. (2) The duplication is polymorphic in the Japan and US natural populations examined. Its frequency is 0.26 on an average in In(2L)t-free chromosomes. (3) Triplication is absent or has not become frequent in the populations surveyed. Possible evolutionary factors of this duplication polymorphism are discussed.
引用
收藏
页码：532 / 535
页数：4
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