PROTON MAGNETIC-RESONANCE STUDY OF THE CONFORMATIONS OF 3',5'-O-(DI-TERT-BUTYLSILANEDIYL) NUCLEOSIDES

被引：1
|
作者：
KATSURA, T [1 ]
UENO, K [1 ]
FURUSAWA, K [1 ]
机构：
[1] RES INST POLYMERS & TEXT,TSUKUBA,IBARAKI 305,JAPAN
来源：
MAGNETIC RESONANCE IN CHEMISTRY | 1993年 / 31卷 / 12期
关键词：
CONFORMATION; 3'; 5'-O-(DI-TERT-BUTYLSILANEDIYL); NUCLEOSIDES; DESERT; H-1; NMR;
D O I：
10.1002/mrc.1260311202
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The solution conformations of nine 3',5'-O-(di-tert-butylsilanediyl) nucleosides, new sila analogues of cyclic nucleotides, were studied by proton NMR spectroscopy. The furanose rings of all the compounds studied are forced to take on the C-3'-endo conformation by the 3',5'-cyclization. The conformations at the glycosidic bond of the adenosine and deoxyadenosine derivatives were determined as mixtures of syn and anti conformations by the DESERT method; the fractions of anti conformation for these derivatives were 0.58 and 0.41, respectively.
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页码：1039 / 1043
页数：5
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