CARDIOPROTECTION BY CU,ZN-SUPEROXIDE DISMUTASE IS LOST AT HIGH-DOSES IN THE REOXYGENATED HEART

被引：130
作者：
OMAR, BA
GAD, NM
JORDAN, MC
STRIPLIN, SP
RUSSELL, WJ
DOWNEY, JM
MCCORD, JM
机构：
[1] Department of Biochemistry, University of South Alabama, Mobile
[2] Department of Physiology, University of South Alabama, Mobile
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 06期
关键词：
MYOCARDIAL ISCHEMIA; REPERFUSION INJURY; FREE RADICALS; SUPEROXIDE DISMUTASE; DOSE-RESPONSE; RAT; RABBIT;
D O I：
10.1016/0891-5849(90)90123-Z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Limited dose-response curves for superoxide dismutase (SOD) were assessed in isolated and in vivo hearts. SOD at 2, 3, 7, 20, or 50 mg/L suppressed CK release in Langendorff rat hearts by 61%, 63%, 72%, and 30%, respectively. SOD at 0.5, 1, 5, and 50 mg/L suppressed LDH release in Langendorff rabbit hearts by 32%, 48%, 54%, and - 12%, respectively. In rabbit hearts subjected to coronary artery ligation and reperfusion in vivo, SOD at 2, 5, or 15 mg/kg reduced infarct size by 10%, 30% or 19%, respectively, while 50 mg/kg increased infarct size by 28%. In conclusion, while SOD was protective at low doses in all models, protection was lost at higher doses in the isolated rat and rabbit hearts, and exacerbation of damage was seen in the in the vivo rabbit hearts.
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收藏
页码：465 / 471
页数：7
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