DELAYED-HYPERSENSITIVITY REACTION TO SUBCUTANEOUS HEPARIN

被引：6

作者：

RIVERS, JK

GIANOUTSOS, MP

机构：

[1] Sydney Melanoma Unit, Department of Surgery, Royal Prince Alfred Hospital, Camperdown, New South Wales

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY | 1991年 / 61卷 / 11期

关键词：

ADVERSE EFFECTS; DELAYED HYPERSENSITIVITY; HEPARIN; LOW MOLECULAR WEIGHT GLYCOSAMINOGLYCANS;

D O I：

10.1111/j.1445-2197.1991.tb00176.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Two women developed well-demarcated eczematous and erythematous plaques localized to the injection sites of subcutaneous preservative-free heparin 72-96 h after heparin administration. The plaques resolved within a week of discontinuing the therapy. Neither epicutaneous testing with preservative-free heparin nor in vitro proliferation assays to heparin and two low molecular weight glycosaminoglycans could elicit a response in either patient. In contrast, both patients developed localized eczematous plaques 48-96 h after re-challenge with intradermal and/or subcutaneous heparin. Delayed hypersensitivity reactions to subcutaneous heparin are uncommon and have not been reported in the Australasian medical literature. Given the frequency with which heparin preparations are used, it is important for physicians and surgeons to be aware of this potential adverse reaction.

引用

页码：865 / 868

页数：4

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