SECRETION OF A POTENTIAL VIRULENCE FACTOR, A FUNGAL RIBONUCLEOTOXIN, DURING HUMAN ASPERGILLOSIS INFECTIONS

被引：70

作者：

LAMY, B ^{[1
]}

MOUTAOUAKIL, M ^{[1
]}

LATGE, JP ^{[1
]}

DAVIES, J ^{[1
]}

机构：

[1] INST PASTEUR,UNITE MYCOL,F-75724 PARIS 15,FRANCE

来源：

MOLECULAR MICROBIOLOGY | 1991年 / 5卷 / 07期

关键词：

D O I：

10.1111/j.1365-2958.1991.tb01930.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We show by cloning and nucleotide sequence analysis that the 18kDa antigen found in the urine of patients suffering from aspergillosis is related to the fungal protein toxins restriction and mitogillin. These are inhibitors of translation which act by catalytic inactivation of eukaryotic ribosomes; they may be implicated in the pathogenesis of the disease.

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页码：1811 / 1815

页数：5

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