SYNTHESIS AND CHEMICAL-REACTIVITY OF C-5 SUBSTITUTED 6,7-BIS-(HYDROXYMETHYL)-1H-PYRROLIZINE BISCARBAMATE TUMOR INHIBITORS

被引：10

作者：

ANDERSON, WK

MACH, RH

机构：

[1] Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 04期

关键词：

D O I：

10.1002/jhet.5570270440

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of C‐5 substituted pyrrolizine biscarbamate alkylating agents were synthesized and evaluated in an in vitro alkylation assay. Introduction of electron‐withdrawing substituents at the C‐5 position resulted in a dramatic decrease in chemical reactivity toward the model nucleophile 4‐(4‐nitrobenzyl)pyridine (NBP). Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：1025 / 1030

页数：6

共 10 条

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[3]

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[8]

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