DIHYDROFOLATE-REDUCTASE - X-RAY STRUCTURE OF BINARY COMPLEX WITH METHOTREXATE

被引:320
|
作者
MATTHEWS, DA
ALDEN, RA
BOLIN, JT
FREER, ST
HAMLIN, R
XUONG, N
KRAUT, J
POE, M
WILLIAMS, M
HOOGSTEEN, K
机构
[1] UNIV CALIF SAN DIEGO, DEPT CHEM, LA JOLLA, CA 92093 USA
[2] UNIV CALIF SAN DIEGO, DEPT BIOL, LA JOLLA, CA 92093 USA
[3] UNIV CALIF SAN DIEGO, DEPT PHYS, LA JOLLA, CA 92093 USA
[4] MERCK INST THERAPEUT RES, RAHWAY, NJ 07065 USA
关键词
D O I
10.1126/science.17920
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:452 / 455
页数:4
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