EFFECTS OF HYPERCHOLECYSTOKININEMIA PRODUCED BY PANCREATICOBILIARY DIVERSION ON PANCREATIC GROWTH AND ENZYME MESSENGER-RNA LEVELS IN STARVED RATS

被引：14
作者：
CHEN, D
ANDERSSON, K
IOVANNA, JL
DAGORN, JC
HAKANSON, R
机构：
[1] UNIV LUND,DEPT PHARMACOL,SOLVEGATAN 10,S-22362 LUND,SWEDEN
[2] NATL INST HLTH & MED RES,UNITE 315,MARSEILLE,FRANCE
[3] ASTRA HASSLE AB,PRECLIN RES DEPT,MOLNDAL,SWEDEN
来源：
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1993年 / 28卷 / 04期
关键词：
CHOLECYSTOKININ; FASTING; PANCREAS; PANCREATICOBILIARY DIVERSION; RATS; MESSENGER RNA; TROPHIC EFFECT;
D O I：
10.3109/00365529309090247
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The purpose of the present study was to examine the weight, DNA content, and enzyme mRNA levels in the pancreas in response to endogenous hypercholecystokininemia produced by pancreaticobiliary diversion (PBD) in starved rats. The results showed that PBD, which is known to increase the circulating cholecystokinin (CCK) concentration, prevented the reduction in the weight and DNA content of the pancreas after 3 days of starving, and that PBD increased the mRNA levels of amylase, chymotrypsinogen B, and procarboxypeptidase A in the pancreas of starved rats. The findings support the view that endogenous CCK plays an important role in maintaining the weight of the normal pancreas of starved rats and that it stimulates the transcription of genes coding for pancreatic exocrine enzymes.
引用
收藏
页码：311 / 314
页数：4
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