STUDIES ON HIGH-GRADE CEREBRAL GLIOMAS

被引：21

作者：

BLEEHEN, NM ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,ADDENBROOKES HOSP,MRC,CLIN ONCOL & RADIOTHERAPEUT UNIT,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1990年 / 18卷 / 04期

基金：

英国医学研究理事会;

关键词：

Astrocytoma; Chemotherapy; Prognostic factors; Radiosensitisers; Radiotherapy;

D O I：

10.1016/0360-3016(90)90401-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A brief review of attempts in the United Kingdom to improve the results of treatment of high grade (grade 3, 4) supra-tentorial astrocytomas is presented. The radiosensitizer misonidazole failed to improve the results of postsurgical radiotherapy, however, multivariate analysis of data from these patients has provided a prognostic index of use in defining good and poor prognosis patients. An overview study of adjuvant nitrosourea therapy trials has shown a small significant advantage for the chemotherapy. A study of chemosensitization by benznidazole of CCNU treatment of patients in relapse failed to demonstrate any effect. © 1990.

引用

页码：811 / 813

页数：3

共 14 条

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WILTSHIRE, CR ;

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[3]

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[4]

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[5]

2-2

[6] HYPOXIC CELL RADIOSENSITIZERS IN THE TREATMENT OF HIGH-GRADE GLIOMAS - A NEW DIRECTION USING COMBINED RO-03-8799 (PIMONIDAZOLE) AND SR-2508 (ETANIDAZOLE) [J].

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[7] A PHASE-I STUDY OF THE COMBINATION OF BENZNIDAZOLE AND CCNU IN MAN [J].

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[8] AN OVERVIEW OF PUBLISHED RESULTS FROM RANDOMIZED STUDIES OF NITROSOUREAS IN PRIMARY HIGH-GRADE MALIGNANT GLIOMA [J].

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