PREVALENCE OF VISUAL DEFICITS IN ALZHEIMERS-DISEASE

被引：92

作者：

MENDOLA, JD

CRONINGOLOMB, A

CORKIN, S

GROWDON, JH

机构：

[1] Department of Brain and Cognitive Sciences, Clinical Research Center, Massachusetts Institute of Technology, Cambridge, MA

[2] Department of Psychology, Boston University, Boston, MA

[3] Massachusetts and Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA

来源：

OPTOMETRY AND VISION SCIENCE | 1995年 / 72卷 / 03期

关键词：

ALZHEIMERS DISEASE; DEMENTIA; VISION; PERCEPTION; PREVALENCE;

D O I：

10.1097/00006324-199503000-00003

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

This study addressed the issue of prevalence and pattern of visual deficits in 77 subjects with Alzheimer's disease (AD) and 111 healthy control subjects. We defined cutoff scores that would be expected from only 1 control subject of 100 (p = 0.01). The percentage of AD subjects who performed at or worse than this level varied across the 16 visual tests from a high of 58% to a low of 0%. The distribution of impairment across tests suggests a high vulnerability in AD of pattern vision, moderate vulnerability of spatial vision, and low vulnerability of motion and flicker perception. We found evidence for heterogeneity in the AD subject group: a subgroup (N = 14) emerged that was characterized by poor performance on the Backward Pattern Masking test, relatively young age, and relatively short duration of AD. Overall, the results indicate that visual dysfunction, especially on Backward Masking, is a common sign of AD.

引用

页码：155 / 167

页数：13

共 73 条

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