NON-STEREOSELECTIVE FORMATION OF 3-ALPHA,7-ALPHA,12-ALPHA,24-TETRAHYDROXY-5-BETA-CHOLESTAN-26-OIC ACID DURING CHOLIC-ACID BIOSYNTHESIS

被引：0
|
作者：
KOBAYASHI, N
HAGIWARA, C
MORISAKI, M
YURI, M
OYA, I
FUJIMOTO, Y
机构：
[1] KYORITSU COLL PHARMACEUT SCI, MINATO KU, TOKYO 105, JAPAN
[2] TOKYO INST TECHNOL, DEPT CHEM, MEGURO KU, TOKYO 152, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 05期
关键词：
BILE ACID; CHOLIC ACID; BETA-OXIDATION; 3-ALPHA; 7-ALPHA; 12-ALPHA-TRIHYDROXY-5-BETA-CHOLESTAN-26-OIC ACID; 12-ALPHA; 24-TETRAHYDROXY-5-BETA-CHOLESTAN-26-OIC ACID; 12-ALPHA-TRIHYDROXY-5-BETA-CHOLEST-24-EN-26-OIC ACID;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Incubation of (25RS)-, (25R)- and (25S)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestan-26-oic acid (THCA, 6, 6a, 66) and (24E)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholest-24-en-26-oic acid (7) with rat Liver mitochondria gave all four stereoisomers (9a, 9b, 9c, 9d) of 3 alpha,7 alpha,12 alpha,24-Tetrahydroxy-5 beta-cholestan-26-oic acid (TeHCA). The corresponding 27-nor analogs (10, 11) were also converted non-stereoselectively to a 1:1 mixture of the epimeric 24-hydroxy compounds (12).
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页码：1028 / 1035
页数：8
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