SYNTHESIS OF NEW GUANIDINE DERIVATIVES FROM 2',3',4',9'-TETRAHYDROSPIRO[PIPERIDINE-4,1'-[1H]PYRIDO[3,4-B]INDOLE]

被引：1
|
作者：
DOMANY, G
GIZUR, T
BARTASZALAI, G
SCHON, I
SZANTAY, C
HEGEDUS, B
机构：
[1] GEDEON RICHTER CHEM WORKS LTD,CHEM WORKS,SPECTROSCOP RES LAB,H-1475 BUDAPEST 10,HUNGARY
[2] GEDEON RICHTER CHEM WORKS LTD,CHEM WORKS,KISFALUDY LAJOS RES LAB,H-1475 BUDAPEST 10,HUNGARY
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 06期
关键词：
D O I：
10.1002/jhet.5570310664
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of the isothiourea derivative 2 with mcthylaminc or pyrrolidine resulted in guanidines 3a-3b. Using hydrazine under the same conditions the tetrazole derivative 4 was obtained. On reacting 2 with piperidine, morpholine, methylhydrazine, phenylhydrazine, hydroxylamine or sodium hydroxide, cyclization took place leading to the novel 4-cyanimino-1,2,3,4,6,7,12, 12b-octahydro-3,12b-ethanopyrimido[1',6':1,2]pyrido[3,4-b]indole (5). Some structural aspects of 5 and other model compounds were analysed mainly by C-13 nmr spectroscopy.
引用
收藏
页码：1657 / 1660
页数：4
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