MITOMYCIN ANALOGS .1. INDOLOQUINONES AS (POTENTIAL) BISALKYLATING AGENTS

被引：92

作者：

OOSTVEEN, EA

SPECKAMP, WN

机构：

来源：

TETRAHEDRON | 1987年 / 43卷 / 01期

关键词：

D O I：

10.1016/S0040-4020(01)89952-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic reduction (H2, Pto2-EtOH) of indoloquinones 7 affords indoloquinones 8. Depending on their leaving group ability one or both substituents X and Y can be eliminated. Evidence is provided, on carrying out the reduction reactions in EtOD, for the intermediacy of quinone methides 10, 12 and/or 13 and iminium derivatives 14.

引用

页码：255 / 262

页数：8

共 39 条

[1]

ANDREWS PA, 1986, J AM CHEM SOC, V108, P4158, DOI 10.1021/ja00274a052

[2]

ANNE A, 1985, NOUV J CHIM, V9, P83

[3] ANTITUMOR ANTHRACYCLINES - RECENT DEVELOPMENTS [J].