Plexus-Specific Detection of Retinal Vascular Pathologic Conditions with Projection-Resolved OCT Angiography

被引：30

作者：

Patel, Rachel C. ^{[1
,2
]}

Wang, Jie ^{[1
]}

Hwang, Thomas S. ^{[1
]}

Zhang, Miao ^{[1
]}

Gao, Simon S. ^{[1
]}

Pennesi, Mark E. ^{[1
]}

Bailey, Steven T. ^{[1
]}

Lujan, Brandon J. ^{[1
]}

Wang, Xiaogang ^{[1
,3
]}

Wilson, David J. ^{[1
]}

Huang, David ^{[1
]}

Jia, Yali ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Casey Eye Inst, Portland, OR USA

[2] Univ Massachusetts, Sch Med, Worcester, MA USA

[3] Shanxi Eye Hosp, Taiyuan, Shanxi, Peoples R China

来源：

OPHTHALMOLOGY RETINA | 2018年 / 2卷 / 08期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

D O I：

10.1016/j.oret.2017.11.010

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To evaluate the projection-resolved (PR) OCT angiography (OCTA) algorithm in detecting plexusspecific vascular abnormalities in retinal pathologic conditions. Design: Cross-sectional observational clinical study Participants: Patients diagnosed with retinal vascular diseases and healthy volunteers. Methods: Eyes were imaged using an OCT system operating at 840 nm and using the split-spectrum amplitude decorrelation algorithm. A novel algorithm suppressed projection artifacts inherent to OCTA. The volumetric scans were segmented and visualized on different plexuses. Main Outcome Measures: Qualitative observation of vascular abnormalities on both cross-sectional and en face PR-OCTA images. Results: Eight illustrative cases are described. In cases of diabetic retinopathy, retinal vessel occlusion, and retinitis pigmentosa, PR-OCTA detected retinal nonperfusion regions within deeper retinal plexuses not visualized by conventional OCTA. In age-related macular degeneration, cross-sectional PR-OCTA allowed the classification of choroidal neovascularization, and, in a case of retinal angiomatous proliferation, identified a vertical vessel contiguous with the deep capillary plexus. In macular telangiectasia, PR-OCTA detected a diving perifoveal vein and delineated subretinal neovascularization. Conclusions: Application of PR-OCTA promises to improve sensitive, accurate evaluation of individual vascular plexuses in multiple retinal diseases. (C) 2017 by the American Academy of Ophthalmology

引用

页码：816 / 826

页数：11

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