LIVER-DIRECTED GENE DELIVERY

被引：21
|
作者：
WU, GY
WU, CH
机构：
[1] Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut School of Medicine, Farmington, CT
来源：
ADVANCED DRUG DELIVERY REVIEWS | 1993年 / 12卷 / 03期
基金：
美国国家卫生研究院;
关键词：
GENES; TARGETING; ASIALOGLYCOPROTEINS; RECEPTORS;
D O I：
10.1016/0169-409X(93)90057-B
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cell surface receptors can provide a convenient natural mechanism for delivery and internalization of substances to cells. We have utilized asialoglycoprotein receptors on hepatocytes to target DNA specifically to these cells. Studies initially began with marker genes in cell culture studies. More recently, normal genes in the form of targetable protein-DNA complexes have been introduced into animals possessing inherited metabolic disorders. Partial, transient corrections of these diseases have been achieved by intravenous injection of the complexed genes.
引用
收藏
页码：159 / 167
页数：9
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