HUMAN RENIN IN TRANSGENIC MOUSE KIDNEY IS LOCALIZED TO JUXTAGLOMERULAR CELLS

被引：36
作者：
FUKAMIZU, A
HATAE, T
KON, Y
SUGIMURA, M
HASEGAWA, T
YOKOYAMA, M
NOMURA, T
KATSUKI, M
MURAKAMI, K
机构：
[1] UNIV TSUKUBA,INST APPL BIOCHEM,SAKURA,IBARAKI 305,JAPAN
[2] HOKKAIDO UNIV,FAC VET MED,DEPT VET ANAT,SAPPORO,HOKKAIDO 060,JAPAN
[3] CENT INST EXPTL,KAWASAKI 213,JAPAN
[4] TOKAI UNIV,SCH MED,DEPT DNA BIOL,ISEHARA,KANAGAWA 25911,JAPAN
来源：
BIOCHEMICAL JOURNAL | 1991年 / 278卷
关键词：
D O I：
10.1042/bj2780601
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To examine whether expression of human renin in the transgenic mouse kidney is regulated in a cell-specific manner, we have characterized monoclonal antibodies against human renin and determined the renin-production site by immunohistochemistry. By using a monoclonal antibody specific for human renin, A6-11-6, we demonstrated that human renin in the transgenic mouse kidney is localized to the juxtaglomerular cells of afferent arterioles.
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页码：601 / 603
页数：3
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