HERPES-VIRUS AND VIRAL-DNA SYNTHESIS IN ULTRAVIOLET LIGHT-IRRADIATED CELLS

被引：36

作者：

COPPEY, J ^{[1
]}

NOCENTINI, S ^{[1
]}

机构：

[1] FDN CURIE, INST RADIUM, BIOL SECT, F-75231 PARIS, FRANCE

来源：

JOURNAL OF GENERAL VIROLOGY | 1976年 / 32卷 / JUL期

关键词：

D O I：

10.1099/0022-1317-32-1-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The rate of virus DNA synthesis and the production of infectious virus are impaired in stationary [African green] monkey kidney CV-1 cells irradiated with UV before infection with herpes simplex virus (HSV). The inhibition of HSV multiplication is due to UV-induced damage in cell DNA. CV-1 cells recover their capacity to support HSV growth 40-48 h after irradiation, and the final virus yield is enhanced by a factor of 10. The time course of the recovery is similar to that of the excision repair process occurring in UV-irradiated mammalian cells. Caffeine, hydroxyurea and cycloheximide inhibit the recovery. Fluorodeoxyuridine is without effect. A small but significant amount of labeled dThd [thymidine] coming from irradiated cell DNA is incorporated into virus DNA. HSV specified thymidine kinase seems more effective for virus DNA synthesis in irradiated than in control cells.

引用

页码：1 / 15

页数：15

共 41 条

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