IN-UTERO TREATMENT OF FETAL GOITROUS HYPOTHYROIDISM CAUSED BY MATERNAL GRAVES-DISEASE

被引:8
作者
HADI, HA [1 ]
STRICKLAND, D [1 ]
机构
[1] E CAROLINA UNIV,SCH MED,DEPT OBSTET & GYNECOL,DIV MATERNAL FETAL MED,GREENVILLE,NC
关键词
GRAVES DISEASE; FETAL GOITROUS HYPOTHYROIDISM; THYROXINE; CARDOCENTESIS;
D O I
10.1055/s-2007-994520
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
We present two cases of maternal Craves' disease complicated by fetal goitrous hypothyroidism. Both patients had elevated maternal thyroid-stimulating immunoglobulin and thyrotropic-binding inhibitory immunoglobulin antibody titers. Diagnosis of fetal hypothyroidism was made by cordocentesis, and serial injections of thyroxine into the amniotic fluid resulted in return to normal of fetal thyroid size and function at birth. Significance of in utero management of fetal hypothyroidism is discussed.
引用
收藏
页码:455 / 458
页数:4
相关论文
共 14 条
[1]  
Wenstrom K.D., Weiner C.P., Williamson R.A., Et al., Prenatal diagnosis of fetal hyperthyroidism using funipuncture, Obstet Gynecol, 76, pp. 513-517, (1990)
[2]  
Hatjis C.G., Diagnosis and successful treatment of fetal goitrous hyperthyroidism caused by maternal Graves' disease, Obstet Gynecol, 81, pp. 837-839, (1993)
[3]  
Porreco R.P., Blach C.A., Fetal blood sampling in the management of intrauterine thyrotoxicosis, Obstet Gynecol, 76, pp. 509-512, (1990)
[4]  
Larsen P.R., Ingbar S.H., The thyroid gland, Williams Textbook of Endocrinology., pp. 357-487, (1992)
[5]  
Davidson K.M., Richards D.S., SchwatZ D.A., Et al., Successful in utero treatment of fetal goiter and hypothyroidism, N Engl J Med, 324, pp. 543-546, (1991)
[6]  
Bromley B., Frigoletto F.D., Cramer D., Et al., The fetal thyroid: normal and abnormal sonographic measurements, J Ultrasound Med, 11, pp. 25-28, (1992)
[7]  
Thorpe-Beeston J.G., Nicolaides K.H., Felton C.V., Et al., Maturation of the secretion ol thyroid hormone and thyroid stimulating hormone in the fetus, N Engl J Med, 324, pp. 532-536, (1991)
[8]  
Zakarija M., McKenzie J.M., Eidson M.S., Transient neonatal hypothyroidism: characterization of maternal antibodies to the thyrotropin receptor, J Clin Endocrinol Med, 70, pp. 1239-1246, (1990)
[9]  
Klein A.H., Oddie T.H., Parslow M., Et al., Developmental changes in pituitary-thyroid function in the human fetus and newborn, Early Hum Dev, 6, pp. 321-330, (1982)
[10]  
Klein H.A., Fisher D.A., Thyrotropin-releasing hormone-stimulated pituitary and thyroid gland responsiveness and 3,5,3-triiodothyronine suppression in fetal and neonatal lambs, Endocrinology, 106, pp. 697-701, (1980)