THE PHARMACOKINETICS OF FLUCONAZOLE DURING HEMODIALYSIS IN UREMIC PATIENTS

被引：0

作者：

OONO, S ^{[1
]}

TABEI, K ^{[1
]}

TETSUKA, T ^{[1
]}

ASANO, Y ^{[1
]}

机构：

[1] JICHI MED SCH,DEPT MED,DIV NEPHROL,3311-1 MINAMIKAWACHI MACHI,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 42卷 / 06期

关键词：

FLUCONAZOLE; HEMODIALYSIS; FUNGAL INFECTION; UREMIA PHARMACOKINETICS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have studied the pharmacokinetics of fluconazole in five patients on long-term haemodialysis. The single-pass extraction rate of the dialyzer was 59 (3.5)% (n = 4), and the serum concentration was reduced by haemodialysis for 3 or 4 h by 26 (3.2)% (n = 5) and 39 (2.2)% (n = 9) respectively. The estimated amount extracted by a dialysis of 4 h was 33 (3.2)% (n = 4) of the dose. During repeated administration the serum fluconazole concentration increased, reaching a plateau at about 4 times the peak concentration after the first dose. After discontinuing administration the serum fluconazole concentration fell by 25% in every 3 h dialysis session. We conclude that fluconazole should be given in the usual dose of 100 or 200 mg at the end of every haemodialysis session.

引用

页码：667 / 670

页数：4

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